|
KMID : 0356920080550030305
|
|
Korean Journal of Anesthesiology
2008 Volume.55 No. 3 p.305 ~ p.307
|
|
|
The effect of injection rate on etomidate-induced myoclonus
|
|
Do Sang-Hwan
Han Sung-Hee
Park Sang-Heon
Kim Jin-Hee
Hwang Jin-Young
Son Il-Soon
Kim Min-Seok
|
|
|
Abstract
|
|
|
Background: Etomidate frequently causes myoclonus. Since the myoclonus is caused by a transient disequilibrium due to etomidate exposure in the CNS, we hypothesized that a slow rate of injection of the drug may decrease the incidence of myoclonus. We conducted a prospective randomized study to compare the effect of two different types of the etomidate injection rate on the incidence and severity of myoclonus.
Methods: Fifty patients were randomly assigned to the fast-injection group (group F) or slow-injection group (group S): Group F patients received etomidate (0.3 mg/kg) over ten seconds. The same dose was administered over two minutes for group S patients. The response to the injection of etomidate was graded on a four-point scale in a blinded manner. The time to loss of consciousness (LOC) was also recorded.
Results: The incidence of myoclonus was significantly lower (P ＜ 0.001) in group S patients; 84% and 28% in group F and group S patients, respectively. The myoclonus was also significantly less severe in group S patients (P ＜ 0.001). The time to LOC was significantly longer in group S patients (106 ± 22 sec) than that of group F patients (49 ± 18 sec, P ＜ 0.001).
Conclusions: With same dose, a slower rate of injection resulted in a lower incidence of myoclonus and can effectively reduce myoclonus without the use of a pretreatment agent.
|
|
|
KEYWORD
|
|
|
etomidate, injection rate, myoclonus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|